Researchers at KEMRI Wellcome Trust Research Programme (KWTRP}

Job Dimensions:

The KEMRI-Wellcome Trust Collaborative Research Programme (KWTRP) researches diseases with the highest burden in developing countries for which it is recognised internationally within the fields of international public health, clinical tropical medicine, epidemiology and immunology. The programme aims to maximise opportunities for learning and training in order to maintain a cadre of highly skilled and experienced staff from all disciplines.

The goal of this funded G2P – Global Knowledge Exchange to Enable In Country Risk Assessment of SARS CoV-2 Variants is to assess the potential for spill-overs into domesticated and wild animal species and subsequent reservoir seeding; undertake in-country virological assessments of future virus outbreaks, and associated virus variants. To do this, the project will perform genomic surveillance of the viruses, immunological profiling and monoclonal antibody discovery. This position will be based at the KEMRI-Wellcome Trust Research Programme but will work collaboratively with external partners. The candidate will be expected to perform flowcytometry, cell sorting, molecular biology techniques such as library preparation, sequencing and sequence analysis and a range of serological assays including ELISA, Luminex and Neutralization.

Reports To:

• Project Principal Investigator

Financial Responsibility:

• None

Key Responsibilities:

Research

• To perform serological assays such as Luminex, ELISA and virus neutralization assays
• To perform molecular biology assays such as cloning, protein expression and purification
• To perform flowcytometry and cell sorting
• To prepare libraries for sequencing and analyse NGS sequencing data
• To manage and update sample shipments from other labs and usage at KWTRP.
• To keep accurate laboratory records on the assay development and data generation
• Prepare and collate results, update relevant databases and prepare reports as may be required.
• To contribute to development of scientific manuscripts

Qualifications:

• A MSc degree in Molecular Biology or Biochemistry or related biological science
• At least 3 years of research experience in a Research Laboratory.
• Practical working knowledge of NGS sequencing.
• The candidate should be familiar with cell culture and serological assays such as ELISA
• The candidate will be expected to organize their work to changing priorities and possess excellent communication and interpersonal skills.
• Evidence of ability to work independently

Desirable:

• Experience in performing virus neutralization assays
• Experience in running sequence analysis pipelines

Physical Environment/Conditions:

• Based at the KEMRI/Wellcome Trust Research Programme in Kilifi, Kenya but flexible to travel to other partner or collaborating institutions
• Be available to work out of hours if necessary.
• Exposure to materials considered infectious and/or biohazards.

Competencies:

• Demonstrate high levels of integrity and confidentiality
• Excellent interpersonal, written, presentation and communication skills
• Good analytical, problem solving and critical thinking skills;
• Teamwork and ability to work with diverse teams
• Strong Flexibility, adaptability, multi-tasking and attention to detail
• Strong team coordination and Supervisory skills.

Job Dimension:

The KEMRI-Wellcome Trust Collaborative Research Programme (KWTRP) researches diseases with the highest burden in developing countries for which it is recognised internationally within the fields of international public health, clinical tropical medicine, epidemiology and immunology. The programme aims to maximise opportunities for learning and training in order to maintain a cadre of highly skilled and experienced staff from all disciplines.

The goal of this funded G2P – Global Knowledge Exchange to Enable In Country Risk Assessment of SARS CoV-2 Variants is to assess the potential for spill-overs into domesticated and wild animal species and subsequent reservoir seeding; undertake in-country virological assessments of future virus outbreaks, and associated virus variants. To do this, the project will perform genomic surveillance of the variants, immunological profiling and monoclonal antibody discovery. This position will be based at the KEMRI-Wellcome Trust Research Programme but will work collaboratively with external partners. The candidate will be expected to perform flowcytometry, cell sorting, library preparation, sequencing and sequence analysis, cloning, expression of mAbs and functional analysis

Reporting To:

• Project Principal Investigator

Financial Responsibility:

• None

Key Responsibilities:

• Supporting the research team in developing protocols for mAb isoloation, bioinformatics analysis and interpretation of large sequencing data sets generated on diverse platforms (NextSeq,MiSeq and NovaSeq).
• Technology transfer from collaborating laboratories.
• Training and supervision of ROs and junior staff
• Designing exploratory analysis approaches and bioinformatics pipelines
• Perform basic molecular biology procedures to generate sequencing libraries.
• Presenting of project results at different forums, locally and internationally.
• Contribute to the writing of scientific manuscripts
• Ensuring that all work done complies with the applicable regulations concerning biohazards, data privacy, Good Clinical and Laboratory Practice and maintain all documentation.
• And any other duties that may be assigned from time to time.

Qualifications:

• A Ph.D. in bioinformatics, data science or molecular biology/immunology
• Upto 4 years Post doc experience
• Experience in analysing large next-generation sequencing data.
• Experience in using various analytical packages such as STATA and R
• The candidate will be expected to organize their work to changing priorities and possess excellent communication and interpersonal skills.
• Evidence of ability to work independently

Desirable:

• Proficiency in programming in Python and software development stacks
• Proficiency with the Pandas Data Library and Jupiter Software Ecosystem

Physical Environment/Conditions:

• Based at the KEMRI/Wellcome Trust Research Programme in Kilifi, Kenya but flexible to travel to other partner or collaborating institutions
• Be available to work out of hours if necessary.
• Exposure to materials considered infectious and/or biohazards.

Competencies:

• Demonstrated high levels of confidentiality and integrity
• Excellent interpersonal, written, presentation and communication skills
• Excellent analytical, problem-solving, and critical thinking skills.
• Strong Management, leadership, and decision-making skills,
• Ability to build strong and diverse effective teams, delegation, and team motivation
• Ability to build productive and collaborative relationships with varied stakeholders